Collaboration
Berberine ursodeoxycholate (HTD1801), is a new molecular entity formed from equimolar amounts of berberine and ursodeoxycholic acid (UDCA). Both berberine and UDCA are traditional natural products with a long history of medicinal use in humans.
Their effectiveness and safety have been well-established and widely recognized. In the form of HTD1801, a salt with a unique microstructure, berberine and UDCA work together to produce distinct and improved properties with "1+1>2" synergistic effects in terms of drug exposure, pharmacokinetics, efficacy, and safety.
Core Product
HTD1801 is a new molecular entity formed from
equimolar amounts of berberine and UDCA.
We focus on addressing significant unmet clinical needs in areas such as metabolic diseases and digestive system disorders, developing novel drugs with multifunctional multi-targeted properties. To deepen our understanding of diseases and explore mechanisms of drugs, we place emphasis on the following research directions:
Non-viral Chronic Liver Disease
● Mechanism of liver fibrosis progression or reversal of fibrosis
● Mechanistic links between liver diseases and cardiovascular diseases
● Rare liver diseases
Diabetes and Cardiovascular Diseases
● Benefits beyond glucose control
● Atherosclerotic diseases
● Heart failure with preserved ejection fraction
Obesity and Metabolic Inflammation
● Regulation of energy metabolism and the control mechanisms of metabolic balance Sarcopenia
● Obesity-related nephropathy
● Anti-aging mechanism
HighTide has multiple drug development programs in metabolic and digestive diseases, and is actively seeking strategic partnerships worldwide to advance the development and expansion of innovative molecules, realizing their clinical and commercial potential.
We anticipate collaborating with scientists, investigators and industry partners to push scientific boundaries in natural products, address global unmet clinical needs, and enhance patient outcomes globally.
To initiate collaboration with HighTide, kindly submit your project description and brief research proposal here:
RESEARCH PROPOSAL
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