论文发表 - 君圣泰医药

Symphony 1：一项评估熊氧去胆小檗碱单药治疗2型糖尿病患者的随机、梯度对照的临床3期研究

Linong Ji, Jianhua Ma, Zhifeng Cheng, Dexue Liu, Hanqing Cai, Sihong Wang, Xiaomei Wang, Yujin Ma, Xiaojing Wang, Jie Han, Guoyue Yuan, Yawei Zhang, Fang Yu, Kui Liu, Meng Yu, Liping Liu. Presented at the ADA 85th Scientific Sessions Conference, June 21-23, 2025.

熊去氧胆小檗碱治疗2型糖尿病：一项随机临床研究

Linong Ji, Jianhua Ma, Yujin Ma, Zhifeng Cheng, Shenglian Gan, Guoyue Yuan, Dexue Liu, Sheli Li, Yu Liu, Xia Xue, Jie Bai, Kun Wang, Hanqing Cai, Shu Li, Kui Liu, Meng Yu, Liping Liu. JAMA Netw Open. 2025;8(3):e2462185. doi:10.1001/jamanetworkopen.2024.62185

熊去氧胆小檗碱（HTD1801）在中国和西方T2DM患者中（无论是否合并MASH）的疗效对比

Shenglian Gan, Linong Ji, Jianhua Ma, Zhifeng Cheng, Nadege T. Gunn, Guy W. Neff, Kui Liu, Leigh MacConell. Presented at the 60th EASD Annual Meeting, September 9-13, 2024.

熊去氧胆小檗碱（HTD1801）为伴有严重胰岛素抵抗的代谢病患者提供独特治疗方案

Leigh MacConell, Alexander Liberman, Abigail Flyer, Kui Liu. Presented at the 60th EASD Annual Meeting, September 9-13, 2024.

在MASH合并T2DM患者中，熊去氧胆小檗碱（HTD1801）组与持续使用GLP-1受体激动剂组的疗效比较

Stephen Harrison, Guy Neff, Nadege Gunn, Abigail Flyer, Leigh MacConell. Presented at the EASL International Liver Congress, June 05-08, 2024.

熊去氧胆小檗碱（HTD1801）改善2型糖尿病疾病谱中关键的血糖和心血管代谢指标

Linong Ji, Jianhua Ma, Yujin Ma, Zhifeng Cheng, Shenglian Gan, Guoyue Yuan, Dexue Liu, Sheli Li, Yu Liu, Xia Xue, Jie Bai, Kun Wang, Hanqing Cai, Shu Li, Kui Liu, Meng Yu, Liping Liu. Presented at the ADA 84th Scientific Sessions, June 21-24, 2024.

对NASH合并T2DM患者在接受HTD1801（熊去氧胆小檗碱）治疗18周后的MRI应答情况的评估

Nadege Gunn, Stephen A. Harrison, Guy Neff, Abigail Flyer, Alexander Liberman, Leigh MacConell. Presented at The Liver Meeting AASLD, November 10-14, 2023.

熊去氧胆小檗碱（HTD1801）改善2型糖尿病患者的血糖控制：一项双盲、安慰剂对照的2期临床研究

Linong Ji, Jianhua Ma, Yujin Ma, Zhifeng Cheng, Shenglian Gan, Guoyue Yuan, Dexue Liu, Sheli Li, Yu Liu, Xia Xue, Jie Bai, Kun Wang, Hanqing Cai, Shu Li, Liping Liu. Presented at the 59th EASD Annual Meeting, October 2-6, 2023.

HTD1801（熊去氧胆小檗碱）在非酒精性脂肪性肝炎合并2型糖尿病患者中显著改善肝纤维炎症（经校正T1加权成像[cT1]评估）

Stephen A. Harrison, Nadege Gunn, Guy Neff, Abigail Flyer, Alexander Liberman, Leigh MacConell. Presented at the EASL International Liver Congress, June 21-24, 2023.

熊去氧胆小檗碱治疗原发性硬化性胆管炎的随机、剂量探索、概念验证性研究

Kris V. Kowdley, Lisa Forman, Bertus Eksteen, Nadege Gunn, Vinay Sundaram, Charles Landis, Stephen A. Harrison, Cynthia Levy, Alexander Liberman, Adrian M. Di Bisceglie, Gideon M. Hirschfield. Am J Gastro. 2022;117(11):1805-15.

HTD1801（熊去氧胆小檗碱）：在代谢疾病及肝病中具有多重获益的独特小分子

Meng Yu, Ru Bai, Xinxiang Fu, Zhaobin Chen, Weijian Liu, Leigh MacConell. Presented at the EASL International Liver Congress, June 22-26, 2022.

HTD1801（熊去氧胆小檗碱）对NASH合并T2DM患者非侵入性纤维化指标的影响

Stephen A. Harrison, Nadege Gunn, Guy Neff, Anita Kohli, Leigh MacConell, Rohit Loomba. Presented at The Liver Meeting AASLD, November 12-15, 2021.

熊去氧胆小檗碱治疗非酒精性脂肪性肝炎合并2型糖尿病患者的随机、对照、概念验证性2期临床研究

Stephen A. Harrison, Nadege Gunn, Guy W. Neff, Anita Kohli, Liping Liu, Abbey Flyer, Lawrence Goldkind, Adrian M. Di Bisceglie. Nat Commun. 2021;12(1):5503.

HTD1801（熊去氧胆小檗碱）对NASH合并T2DM患者心血管代谢的影响

Guy Neff, Anita Kohli, Nadege Gunn, Abigail Flyer, Leigh MacConell, Stephen Harrison. Presented at the 7th Paris NASH Meeting, September 9-10, 2021.

HTD1801（熊去氧胆小檗碱）在高脂血症患者中的药代动力学与药效学评价

Adrian Di Bisceglie, Gerald Watts, Philip Lavin, Meng Yu, Ru Bai, Liping Liu. Lipids Health Dis. 2020;19(1):239.

一种结构及血浆稳定性更佳的新型胰岛再生相关蛋白类似物

Soledad Lynn, Yanis Ricardo Espinosa Silva, Luis Diambra, Andres Norman McCarthy, Liping Liu, Ru Bai, Carolina Lisi Roman, Barbara Maiztegui, Luis Emilio Flores, Juan Jose Gagliardino. J Biomol Struct Dyn. 2021;39(3):766-776.