{"id":2016,"date":"2026-06-08T01:32:59","date_gmt":"2026-06-07T17:32:59","guid":{"rendered":"https:\/\/www.hightidetx.com\/cn\/?p=2016"},"modified":"2026-06-08T01:33:01","modified_gmt":"2026-06-07T17:33:01","slug":"%e9%87%8d%e7%a3%85%e5%8f%91%e5%b8%83%ef%bd%9c%e5%90%9b%e5%9c%a3%e6%b3%b0%e5%8c%bb%e8%8d%afhtd1801%e4%b8%b4%e5%ba%8aiii%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%bb%93%e6%9e%9c%e5%8f%91%e8%a1%a8%e4%ba%8e%e6%96%b0","status":"publish","type":"post","link":"https:\/\/www.hightidetx.com\/cn\/2026\/06\/08\/%e9%87%8d%e7%a3%85%e5%8f%91%e5%b8%83%ef%bd%9c%e5%90%9b%e5%9c%a3%e6%b3%b0%e5%8c%bb%e8%8d%afhtd1801%e4%b8%b4%e5%ba%8aiii%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%bb%93%e6%9e%9c%e5%8f%91%e8%a1%a8%e4%ba%8e%e6%96%b0\/","title":{"rendered":"\u91cd\u78c5\u53d1\u5e03\uff5c\u541b\u5723\u6cf0\u533b\u836fHTD1801\u4e34\u5e8aIII\u671f\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u4e8e\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u4e34\u5e8a\u8bc1\u636e\u5b50\u520a\uff0cCKM\u7efc\u5408\u6cbb\u7597\u6f5c\u529b\u518d\u83b7\u56fd\u9645\u8ba4\u53ef"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"309\" src=\"https:\/\/www.hightidetx.com\/cn\/wp-content\/uploads\/sites\/2\/2026\/06\/\u56fe\u72471-1024x309.jpg\" alt=\"\" class=\"wp-image-2018\" style=\"width:1600px;height:auto\" srcset=\"https:\/\/www.hightidetx.com\/cn\/wp-content\/uploads\/sites\/2\/2026\/06\/\u56fe\u72471-1024x309.jpg 1024w, https:\/\/www.hightidetx.com\/cn\/wp-content\/uploads\/sites\/2\/2026\/06\/\u56fe\u72471-300x90.jpg 300w, https:\/\/www.hightidetx.com\/cn\/wp-content\/uploads\/sites\/2\/2026\/06\/\u56fe\u72471-768x232.jpg 768w, https:\/\/www.hightidetx.com\/cn\/wp-content\/uploads\/sites\/2\/2026\/06\/\u56fe\u72471-1536x463.jpg 1536w, https:\/\/www.hightidetx.com\/cn\/wp-content\/uploads\/sites\/2\/2026\/06\/\u56fe\u72471-2048x618.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n<ul class=\"wp-block-list\">\n<li><em>\u7814\u7a76\u7ed3\u679c\u5c55\u73b0\u4e86HTD1801\u5177\u6709\u663e\u8457<\/em><em>\u4e14\u6301\u4e45\u7684\u964d\u7cd6\u6548\u679c<\/em><em>\uff0c\u4e14\u4f53\u73b0\u4e86\u5176\u5728\u6539\u5584\u5fc3\u80be\u4ee3\u8c22\u75be\u75c5\u5371\u9669\u56e0\u7d20\u7684\u7efc\u5408\u83b7\u76ca\u4ef7\u503c<\/em><\/li>\n\n\n\n<li><em>\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u53d7\u7406\uff0cHTD1801<\/em><em>\u8fc8\u5411<\/em><em>\u5546\u4e1a\u5316<\/em><em>\u9636\u6bb5<\/em><\/li>\n<\/ul>\n\n\n\n<p>\u4e2d\u56fd\u6df1\u5733\u3001\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\uff0c2026\u5e746\u67088\u65e5<strong>\u2014\u2014<\/strong>\u541b\u5723\u6cf0\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a2511.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u5fc3\u80be\u4ee3\u8c22\u7cfb\u7edf\u75be\u75c5(CKM)\u3001\u5f00\u53d1\u591a\u529f\u80fd\u591a\u9776\u70b9\u7597\u6cd5\u7684\u521b\u65b0\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u5ba3\u5e03HTD1801\u8054\u5408\u4e8c\u7532\u53cc\u80cd\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\uff08T2DM\uff09\u7684\u4e34\u5e8aIII\u671f\u7814\u7a76\uff08SYMPHONY-2\uff09\u4e3b\u8981\u7ed3\u679c<a href=\"https:\/\/evidence.nejm.org\/doi\/full\/10.1056\/EVIDoa2500317\">\u53d1\u8868<\/a>\u4e8e\u56fd\u9645\u77e5\u540d\u533b\u5b66\u671f\u520a\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b(NEJM)\u4e34\u5e8a\u8bc1\u636e\u5b50\u520a\u300aNEJM Evidence\u300b\u3002\u540c\u65f6\uff0c\u5728\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a\uff08ADA\uff09\u7b2c86\u5c4a\u79d1\u5b66\u4f1a\u8bae\u4e0a\uff0c\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u5185\u5206\u6ccc\u79d1\u4e3b\u4efb\u3001SYMPHONY-2\u7684\u7275\u5934\u7814\u7a76\u8005\u3001\u6587\u7ae0\u901a\u8baf\u4f5c\u8005\u7eaa\u7acb\u519c\u6559\u6388\u51fa\u5e2d\u5e76\u53d1\u5e03\u7ed3\u679c\u3002<\/p>\n\n\n\n<p>SYMPHONY-2\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30HTD1801\u5728\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u540e\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73\u7684\u6210\u4ebaT2DM\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u53d1\u8868\u4e8e\u300aNEJM Evidence\u300b\u7684\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8840\u7cd6\u63a7\u5236\uff1a<\/strong>\u7b2c24\u5468\u65f6\uff0c\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0cHTD1801\u7ec4\u7684HbA1c\u8f83\u57fa\u7ebf\u5e73\u5747\u53d8\u5316\u4e3a-1.2%\uff1bHTD1801\u7ec4\u8fbe\u5230\u201cHbA1c\u4f4e\u4e8e7%\u201d\u7684\u63a7\u7cd6\u76ee\u6807\u7684\u60a3\u8005\u6bd4\u4f8b\u663e\u8457\u9ad8\u4e8e\u5b89\u6170\u5242\u7ec4\uff0833% vs. 11%\uff09\u3002\u7b2c52\u5468\u65f6\uff0c\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u6301\u7eed\u63a5\u53d7HTD1801\u6cbb\u7597\u7684\u60a3\u8005HbA1c\u8f83\u57fa\u7ebf\u53d8\u5316\u4e3a-1.1%\uff1b\u5728\u53cc\u76f2\u671f\u63a5\u53d7\u5b89\u6170\u5242\u5e76\u4e8e\u5f00\u653e\u5ef6\u957f\u6cbb\u7597\u671f\u8f6c\u6362\u4e3aHTD1801\u6cbb\u7597\u7684\u60a3\u8005HbA1c\u8f83\u57fa\u7ebf\u53d8\u5316\u4e3a-1.2%\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cHTD1801\u8054\u5408\u4e8c\u7532\u53cc\u80cd\u6cbb\u7597\u53ef\u5e26\u6765\u663e\u8457\u4e14\u6301\u4e45\u7684\u8840\u7cd6\u63a7\u5236\u6548\u679c\u3002<\/li>\n\n\n\n<li><strong>\u5fc3\u8840\u7ba1\u4ee3\u8c22\u4e0e\u6297\u708e\u83b7\u76ca\uff1a<\/strong>\u7b2c24\u5468\u65f6\uff0cHTD1801\u7ec4\u5728\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\uff08\u221213.6 vs. 0.2 mg\/dl\uff09\u4e0e\u03b3-\u8c37\u6c28\u9170\u8f6c\u79fb\u9176\uff08GGT\uff09\uff08\u22124.4 vs. 0.6 U\/l\uff09\u65b9\u9762\u5747\u663e\u793a\u51fa\u663e\u8457\u964d\u5e45\u3002\u5fc3\u8840\u7ba1\u4ee3\u8c22\u53ca\u708e\u75c7\u76f8\u5173\u6307\u6807\u7684\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u5728\u7b2c24\u5468\u5747\u8f83\u5b89\u6170\u5242\u7ec4\u83b7\u5f97\u663e\u8457\u6539\u5584\uff0c\u4e14\u76f8\u5173\u6cbb\u7597\u6548\u679c\u6301\u7eed\u81f352\u5468\u3002<\/li>\n\n\n\n<li><strong>\u5b89\u5168\u6027\uff1a<\/strong>\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4f4e\u3002\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u8179\u6cfb\uff0c\u4e14\u5927\u591a\u6570\u75c5\u4f8b\u4e3a\u8f7b\u81f3\u4e2d\u5ea6\uff0c\u5e76\u968f\u7740\u65f6\u95f4\u63a8\u79fb\u9010\u6e10\u6539\u5584\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5317\u4eac\u5927\u5b66\u7cd6\u5c3f\u75c5\u4e2d\u5fc3\u4e3b\u4efb\u3001\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662\u5185\u5206\u6ccc\u79d1\u4e3b\u4efb\u7eaa\u7acb\u519c\u6559\u6388\u8868\u793a\uff1a<\/strong>\u201c\u5f53\u524d\u4e0e\u7cd6\u5c3f\u75c5\u76f8\u5173\u7684\u65b0\u836f\u7814\u53d1\u8d44\u6e90\u51e0\u4e4e\u90fd\u96c6\u4e2d\u5728\u5f00\u53d1GLP-1\u76f8\u5173\u7684\u836f\u7269\u3002\u867d\u7136GLP-1\u76f8\u5173\u836f\u7269\u57282\u578b\u7cd6\u5c3f\u75c5\u6cbb\u7597\u4e2d\u83b7\u5f97\u5de8\u5927\u6210\u529f\uff0c\u4f46\u5e76\u4e0d\u662f\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u7ec8\u6781\u6b66\u5668\uff0c\u6211\u4eec\u4ecd\u7136\u9700\u8981\u5f00\u53d1\u66f4\u591a\u7684\u836f\u7269\u6765\u8fdb\u4e00\u6b65\u6ee1\u8db3\u7cd6\u5c3f\u75c5\u7ba1\u7406\u4e2d\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u3002HTD1801\u51ed\u501f\u5176\u6fc0\u6d3bAMPK\u5e76\u6291\u5236NLRP3\u7684\u72ec\u7279\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff0c\u5728SYMPHONY-2\u7814\u7a76\u4e2d\u8868\u73b0\u51fa\u4f18\u5f02\u4e14\u6301\u4e45\u7684\u964d\u7cd6\u3001\u964d\u4f4e\u8840\u8102\u3001\u51cf\u8f7b\u708e\u75c7\u3001\u6539\u5584\u80be\u810f\u529f\u80fd\u7b49\u591a\u91cd\u83b7\u76ca\u3002\u8fd9\u4e00\u7efc\u5408\u7597\u6548\u4f7fHTD1801\u4e0d\u4ec5\u6709\u671b\u6210\u4e3a\u6ee1\u8db3\u66f4\u591aT2DM\u60a3\u8005\u4e2a\u4f53\u5316\u6cbb\u7597\u9700\u6c42\u7684\u521b\u65b0\u6cbb\u7597\u9009\u62e9\uff0c\u66f4\u6709\u6f5c\u529b\u6210\u4e3a\u5fc3\u80be\u4ee3\u8c22\u7cfb\u7edf\u75be\u75c5\uff08CKM\uff09\u7684\u65b0\u6cbb\u7597\u836f\u7269\u3002\u76f8\u4fe1SYMPHONY-2\u7814\u7a76\u7684\u6210\u529f\u80fd\u4e3aHTD1801\u7684\u83b7\u6279\u4e0a\u5e02\u63d0\u4f9b\u6709\u529b\u7684\u652f\u6301\u3002\u201d<\/p>\n\n\n\n<p><strong>\u541b\u5723\u6cf0\u533b\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u517c\u9996\u5e2d\u6267\u884c\u5b98\u5218\u5229\u5e73\u535a\u58eb\u8868\u793a\uff1a<\/strong>\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174SYMPHONY-2\u7814\u7a76\u6210\u679c\u80fd\u591f\u83b7\u5f97\u300aNEJM Evidence\u300b\u7684\u8ba4\u53ef\u3002\u4f5c\u4e3a\u4e00\u6b3e\u5168\u7403\u9996\u521b\u7684\u591a\u529f\u80fd\u591a\u9776\u70b9\u65b0\u836f\uff0cHTD1801\u5df2\u5728\u591a\u4e2a\u4e34\u5e8a\u7814\u7a76\u4e2d\u5145\u5206\u5c55\u73b0\u4e86\u5176\u4f5c\u4e3aCKM\u57fa\u7840\u7597\u6cd5\u7684\u4e34\u5e8a\u6f5c\u529b\u3002\u76ee\u524d\uff0c\u6211\u4eec\u6b63\u79ef\u6781\u63a8\u8fdbHTD1801\u7684\u4e0a\u5e02\u53ca\u5546\u4e1a\u5316\u76f8\u5173\u5de5\u4f5c\uff0c\u671f\u5f85\u5c3d\u65e9\u5c06\u8fd9\u4e00\u521b\u65b0\u7597\u6cd5\u5e26\u7ed9\u5168\u7403CKM\u75be\u75c5\u60a3\u8005\u3002\u201d<\/p>\n\n\n\n<p><strong>\u5173\u4e8eHTD1801<\/strong><strong><\/strong><\/p>\n\n\n\n<p>HTD1801\u662f\u4e00\u6b3e\u5168\u7403\u9996\u521b\u7684\u65b0\u5206\u5b50\u5b9e\u4f53\uff0c\u65e8\u5728\u89e3\u51b3\u5fc3\u80be\u4ee3\u8c22\u7cfb\u7edf\u75be\u75c5\uff08CKM\uff09\u7684\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\u3002HTD1801\u4f5c\u4e3a\u5355\u4e00\u5206\u5b50\uff0c\u662f\u5177\u6709\u72ec\u7279\u53cc\u673a\u5236\u7684\u53e3\u670d\u6297\u708e\u53ca\u4ee3\u8c22\u8c03\u8282\u5242\uff08AIMM\uff09\uff0c\u901a\u8fc7\u6fc0\u6d3bAMPK\u53ca\u6291\u5236NLRP3\u708e\u75c7\u5c0f\u4f53\u53d1\u6325\u5176\u751f\u7269\u5b66\u6d3b\u6027\uff1b\u8fd9\u79cd\u4e92\u8865\u534f\u540c\u7684\u53cc\u673a\u5236\u4f5c\u7528\u53ef\u6709\u6548\u89e3\u51b3\u4ee3\u8c22\u95ee\u9898\u3002\u5168\u7403\u591a\u9879\u4e34\u5e8a\u7ed3\u679c\u9a8c\u8bc1HTD1801\u5177\u6709\u201c\u4e00\u836f\u591a\u6548\u201d\u7684\u7279\u6027\uff0c\u80fd\u591f\u4e3a\u60a3\u8005\u5e26\u6765\u7efc\u5408\u83b7\u76ca\uff0c\u5305\u62ec\u6539\u5584\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u3001\u8840\u7cd6\u63a7\u5236\u3001\u8840\u8102\u964d\u4f4e\u3001\u80be\u810f\u4fdd\u62a4\u3001\u4f53\u91cd\u51cf\u8f7b\u3001\u809d\u810f\u83b7\u76ca\u53ca\u6297\u708e\u7b49\u3002\u57fa\u4e8e\u6b64\uff0cHTD1801\u6709\u6f5c\u529b\u6210\u4e3aCKM\u9886\u57df\u7684\u57fa\u7840\u6027\u6cbb\u7597\u836f\u7269\u3002<\/p>\n\n\n\n<p><strong>\u5173\u4e8e\u541b\u5723\u6cf0\u533b\u836f<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u541b\u5723\u6cf0\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a2511.HK\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u5fc3\u80be\u4ee3\u8c22\u7cfb\u7edf\u75be\u75c5\uff08CKM\uff09\u3001\u5f00\u53d1\u591a\u529f\u80fd\u591a\u9776\u70b9\u7597\u6cd5\u7684\u521b\u65b0\u751f\u7269\u533b\u836f\u516c\u53f8\u3002\u7acb\u8db3\u6e90\u5934\u521b\u65b0\uff0c\u516c\u53f8\u81f4\u529b\u4e8e\u5f00\u53d1\u7a81\u7834\u6027\u7597\u6cd5\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6807\u672c\u517c\u6cbb\u3001\u7efc\u5408\u83b7\u76ca\u7684\u89e3\u51b3\u65b9\u6848\u3002\u516c\u53f8\u5df2\u5efa\u7acb100%\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u5168\u7403\u5316\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5728\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u5f00\u5c55\u4e86\u9488\u5bf9CKM\u75be\u75c5\u591a\u9879\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\u7814\u7a76\u3002\u516c\u53f8\u6838\u5fc3\u4ea7\u54c1HTD1801\u5df2\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff092\u9879\u5feb\u901f\u901a\u9053\u4e0e1\u9879\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3001\u4ee5\u53ca\u5341\u4e09\u4e94\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u56fd\u5bb6\u79d1\u6280\u91cd\u5927\u4e13\u9879\u3002<\/p>\n\n\n\n<p>\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u516c\u53f8\u5b98\u7f51\uff1a<a href=\"http:\/\/www.hightidetx.com\"><u>www.hightidetx.com<\/u><\/a>\uff0c\u6216\u8054\u7cfb\u516c\u53f8\u54c1\u724c\u90e8\uff1a<a href=\"mailto:pr@hightidetx.com\"><u>pr@hightidetx.com<\/u><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u56fd\u6df1\u5733\u3001\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\uff0c2026\u5e746\u67088\u65e5\u2014\u2014\u541b\u5723\u6cf0\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a2511.HK\uff09\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u5fc3\u80be\u4ee3 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-2016","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ 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